Low-dose cyclosporin for multiple colonic ulcers associated with mixed connective tissue disease

This report describes a patient with multiple colonic ulcers and mixed conn ective tissue disease. The histological findings of the colonic lesions sho wed vasculitis with T-cell infiltration, and the peripheral T cells were fr equently in the activated phase of the cell cycle. In this patient, low-dos e cyclosporin treatment (2.5 mg/kg/day) inhibited the T-cell activation in the peripheral lymphocytes and was very effective in the gastrointestinal d isorder, which might be related to T-cell activation. This case suggests th e possibility that even low-dose cyclosporin can exert a great influence on peripheral T cells and directly inhibit T-cell activation, thereby improvi ng symptoms related to T-cell activation.