Although the intestinal amebae that infect humans are not thought of as cla
ssic agents of food-borne disease, food plays an important role in the tran
smission of these protozoa. This is particularly true for areas of the worl
d where the organisms are endemic. Transmission of most intestinal protozoa
occurs by the fecal-oral route via contaminated food or water. Among the f
our genera of amebae that infect man, only Entamoeba histolytica and Blasto
cystis hominis are causes of disease. This article focuses on E. histolytic
a because of the organism's medical and economic impact on humans. In addit
ion, the epidemiology, control, and laboratory diagnosis of these protozoa
are addressed.