Conjunctival epithelial neoplasias in organ transplant patients receiving cyclosporine therapy

Purpose. To report two cases of conjunctival epithelial neoplasias occurrin g after long-term systemic cyclosporine therapy in organ transplant recipie nts. Methods, Case report. Each patient underwent an excision of an extensi ve limbal conjunctival lesion, followed by a histopathologic analysis. Resu lts. Histopathologic examination results revealed a carcinoma in situ and a squamous cell carcinoma in patients 1 and 2, respectively. Recurrence occu rred in patient 1, who needed topical mitomycin C 0.02% treatment. No recur rence was observed in patient 2 after a follow-up of 24 months. Conclusion. To our knowledge, these are the first reported cases of its kind after lon gterm systemic cyclosporine therapy. Further studies will be needed to dete rmine the exact role of cyclosporine in the induction of conjunctival epith elial neoplasias and the need for regular ophthalmologic examination of tra nsplant recipients.