Classification of herpes simplex virus keratitis and anterior uveitis

Purpose. To review the classification of herpes simplex virus (HSV) keratit is and anterior uveitis using the available clinical, pathologic, and labor atory models of disease. Methods. The literature was reviewed to establish prior classifications of herpes simplex keratitis and uveitis. The author i ntroduces a classification attempting to encompass all patients with this d isease process, taking into account the newer proposed mechanisms of diseas e. Results. A classification of HSV keratitis and uveitis is introduced bas ed on the literature and the experience of the author in treating patients with this condition. Conclusions, There are multiple mechanisms of disease after ocular HSV infection, including damage from live virus, from immune a nd inflammatory mechanisms, and from structural damage in the aftermath of HSV infection (metaherpetic disease). Clinical, pathologic, and etiologic d escriptions of these disease manifestations an offered. This may allow bett er communication between clinicians and authors of research protocols by de fining the different aspects of this complex disease process.