Methods for X-ray diffraction analysis of macromolecular structures

A modern approach to protein crystallography relies as much on molecular bi ology as on the 'core' crystallographic disciplines. Some recent, biologica lly significant structure determinations have demonstrated this and show th e importance of new third generation synchrotron sources. Novel uses of wel l known phasing techniques have also been valuable in these structure deter minations. For the majority of structures, advances in phasing techniques, data collection and processing and the associated computer programs have le d to more effective structure determinations.