Analysis of macromolecular structure and dynamics by electron cryo-microscopy

Authors
Kuhlbrandt, W Williams, KA
Citation
W. Kuhlbrandt et Ka. Williams, Analysis of macromolecular structure and dynamics by electron cryo-microscopy, CURR OP C B, 3(5), 1999, pp. 537-543
Citations number
62
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
3
Issue
5
Year of publication
1999
Pages
537 - 543
Database
ISI
SICI code
1367-5931(199910)3:5<537:AOMSAD>2.0.ZU;2-E
Abstract
Electron cryo-microscopy has yielded a wealth of detailed new information o n structures of biological macromolecules ranging from alpha beta-tubulin a t 3.7 Angstrom resolution to hepatitis B virus at 7.4 Angstrom resolution, as well as a number of membrane proteins at 6-8 Angstrom resolution. Much o f this progress was made possible by recent advances in instrumentation and image processing techniques.