Structure and mechanism of ATP-dependent proteases

Authors
Schmidt, M Lupas, AN Finley, D
Citation
M. Schmidt et al., Structure and mechanism of ATP-dependent proteases, CURR OP C B, 3(5), 1999, pp. 584-591
Citations number
51
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
13675931 → ACNP
Volume
3
Issue
5
Year of publication
1999
Pages
584 - 591
Database
ISI
SICI code
1367-5931(199910)3:5<584:SAMOAP>2.0.ZU;2-2
Abstract
A general paradigm for energy-dependent proteases is emerging: ATP may be u sed to unfold the substrate and translocate it through a narrow channel wit hin the enzyme into a central proteolytic chamber. Different members of the family present intriguing elaborations on this model.