Organic leachables from polymer-based dental filling materials

Results are reported from a study on the in vitro separation and identifica tion of leachables from three different polymer-based dental filling materi als by using a combined method of gas chromatography and mass spectrometry. The median number of separable organic leachables in these materials was b etween 14 and 22. Of these organic leachables the following were identified and quantified: DL-camphorquinone, 4-dimethylaminobenzoic acid ethyl ester (DMABEE), drometrizole, 1,7,7-trimethylbicyclo[2,2,1]heptane, 2,2-dimethox y[1,2] diphenyletanone (DMBZ), ethyleneglycol dimethacrylate (EGDMA), and t riethyleneglycol dimethacrylate (TEGDMA). Three of the leachables have prev iously been shown to provoke allergy. The range of log P-ow values (represe nting the lipophilicity of these compounds) varied between 1.09 and 4.20. B y multivariate data analysis, selected leachables from the tested materials were shown to separate into characteristic patterns. The results contribut e to a characterization of potential hazardous compounds in polymer-based d ental filling materials.