Recurrent DNA copy number losses associated with metastasis of larynx carcinoma

Squamous cell carcinomas of the head and neck show frequent and complex chr omosome aberrations, but little is known about the changes that occur durin g the metastatic process. To compare the accumulation of changes in primary and metastatic tumors we analyzed 19 pairs of primary larynx cancer tumors and their metastases. The most frequent changes were found at 3p, 3q, 5p, 9, and 13. Losses at 13, 8p, and 9q were more frequent in metastases than i n primary tumors. (C) 1999 Wiley-Liss, Inc.