Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts

Aneurysmal bone cyst (ABC) is a benign bone lesion for which no previous cy togenetic data exist. We describe the finding of clonal chromosome aberrati ons in three tumors; two had a t(16;17)(q22;p13) as the sole anomaly, and t he third had a del(16)(q22) as the only change. These findings show that so matic mutations contribute to the development of ABC and furthermore indica te that bands 16q22 and 17p13 may harbor genes of importance in this proces s. (C) 1999 Wiley-Liss, Inc.