Cancer therapy: New concepts on active immunization

Citation
M. Zoller et S. Matzku, Cancer therapy: New concepts on active immunization, IMMUNOBIOL, 201(1), 1999, pp. 1-21
Citations number
239
Categorie Soggetti
Immunology
Journal title
IMMUNOBIOLOGY
ISSN journal
01712985 → ACNP
Volume
201
Issue
1
Year of publication
1999
Pages
1 - 21
Database
ISI
SICI code
0171-2985(199909)201:1<1:CTNCOA>2.0.ZU;2-E
Abstract
There is increasing evidence that tumors express putative target molecules for a therapeutic immune reaction. Yet, tumor cells lack the prerequisites for appropriate antigen presentation and - hence - the immune system does n ot respond. This difficulty can probably be circumvented when tumor antigen s are processed by conventional antigen presenting cells. Thus, the identif ication of immunogenic tumor-associated antigens may allow new modes of vac cination with the hope of adding a fourth and hopefully powerful weapon to surgery, radiation and chemotherapy in the fight against cancer.