Decreased expression of CD44 in metastatic prostate cancer

Decreased expression of CD44 is an independent prognostic marker for surgic ally treated prostate cancer. To investigate immunohistochemically defined CD44 expression in primary and metastatic prostate cancer, 2 groups of pati ents undergoing radical prostatectomy for clinically localized prostate can cer were studied. (1) pN(1) group: 23 patients, finally staged pN(1), of wh om the radical prostatectomy specimen and the lymph nodes were investigated to establish a correlation between CD44 expression in the concurrently res ected primaries and metastases; (2) pN(0) group: 23 patients with pN(0) dis ease matched for pT stage and Gleason sum score with the pN(1) patients. Pr ogression rates based on serum prostate-specific antigen (PSA) levels could be determined in 42 of these 46 patients. In addition, 28 distant metastas es were studied. A CD44 score of < 10% was found in 22 of the 23 lymph node metastases (96%) and in 20 of the corresponding radical prostatectomies. I n the pN(0) group this was observed in only 6 out of 23 specimens. In most of the distant metastases CD44 scores were < 10%. Patients with pN(0) disea se and > 10% CD44-positive tumor cells had a significantly better prognosis than the other patients who were not significantly different from each oth er. CD44 expression is thus strongly reduced in prostate cancer metastases as well as in the corresponding primary tumors. This reduction may be used to predict the N stage clinically, provided that CD44 scores can be determi ned reliably on preoperative biopsy specimens. Int. J. Cancer (Pred. Oncol. ) 84:478-483, 1999. (C) 1999 Wiley-Liss, Inc.