K. Hatano et al., Evaluation of the therapeutic effect of radiotherapy on cervical cancer using magnetic resonance imaging, INT J RAD O, 45(3), 1999, pp. 639-644
Citations number
26
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Purpose: This study was performed to evaluate magnetic resonance imaging (M
RI) in determining the therapeutic effect of radiotherapy (RT) on cervical
cancer.
Methods and Materials: Serial MRI studies were performed in 42 patients wit
h predominantly advanced cervical cancer before, during, and after radiothe
rapy. Patients underwent external irradiation combined with high-dose-rate
intracavitary (HDR) brachytherapy. T-2 weighted spin-echo pulse sequences w
ith long repetition and echo times were used at a field strength of 1.5 T.
Multiple punch biopsies of the cervix were obtained from the high-signal in
tensity area in all patients at the same time as the MRI.
Result: In biopsies performed immediately after RT, no residual tumors were
found in 36 patients (86%); in 6 patients, residual tumors were observed.
The simultaneous MRI study demonstrated no high-signal intensity on T2-weig
hted images in 28 patients. A high-signal area was observed in 14 patients,
and this disappeared 3 months after RT in 8 patients with a negative histo
logical study. The sensitivity, specificity, and accuracy of MRI studies at
3 months after RT were 100%. When the relationship between reduction of tu
mor volume at 30 Gy and local tumor control was analyzed, every patient wit
h a reduction under 30% gained local control. Also, patients with no residu
al tumors 3 months after RT gained local control.
Conclusion: MRI studies performed at 30 Gy of external irradiation and 3 mo
nths after RT were predictive factor of local control. (C) 1999 Elsevier Sc
ience Inc.