Lipid bilayer experiments indicated that the cell wall of Mycobacterium tub
erculosis contains at least two different porins: (i) a cation-selective, h
eat-sensitive 0.7-nS channel which has a short-lived open state and is prob
ably composed of 15-kDa subunits and (ii) a 3-nS, >60-kDa channel with a lo
ng-lived open state, resembling porins from fast-growing mycobacteria.