Ja. Keelan et al., Concentrations of activin A, inhibin A and follistatin in human amnion, choriodecidual and placental tissues at term and preterm, J ENDOCR, 163(1), 1999, pp. 99-106
To investigate labour-associated changes in production of activin and relat
ed hormones by gestational tissues we prepared extracts from amnion, chorio
decidual and placental tissues delivered at term before labour (TNL; n=15),
at term after spontaneous labour (TSL; n=15) or preterm (PTD; n=31) and me
asured concentrations of inhibin A, activin A and follistatin by ELISA. Act
ivin concentrations in placental tissues were significantly (Mann-Whitney U
-test; P<0.05) elevated with term labour (pg/mg protein, median; 1313 vs 25
91), but in the PTD tissues concentrations were lower than those delivered
spontaneously at term (3650 vs 2649). Inhibin concentrations also increased
with term labour in the placenta (480 vs 686), but paradoxically decreased
in amnion (188 vs 64) and choriodecidua (657 vs 358). Little or no signifi
cant changes in follistatin concentrations were observed. Concentrations of
all three proteins were significantly correlated between amnion and chorio
decidual tissues, and were significantly correlated with each other in most
tissues (Spearman's ranked correlation; P<0.05). The activin:inhibin ratio
in term amnion and choriodecidual tissues was increased 2 to 3-fold (P<0.0
005 by Mann-Whitney U-test) after term labour, with similar trends also obs
erved in the activin:follistatin ratio in placental tissue. These data sugg
est that a modest increase in placental activin and inhibin production may
occur with labour at term. In addition, an increase in activin bioactivity
may occur with labour, potentiating any paracrine effects of activin during
parturition. The data, however, do not support an association between incr
eased intrauterine activin biosynthesis and preterm delivery.