Although early syphilis morbidity in New York City (NYC) has declined to a
record low, syphilis seroreactivity among women jailed in NYC is similar to
25%. By use of a retrospective cohort-type analysis of longitudinal serolo
gic and treatment data collected at the time of each incarceration, the inc
idence of syphilis infection among 3579 susceptible women jailed multiple t
imes in NYC between 23 March 1993 and 10 April 1997 was estimated. Syphilis
incidence densities were estimated by use of continuous, time-homogeneous
Markov models. There was a total of 289 incident infections. The overall in
cidence density was 6.5 infections per 100 woman-years (95% confidence inte
rval, 5.7-7.2), which exceeds the 1997 early syphilis rate among women in N
YC by >1000-fold. The persisting high incidence of syphilis in this populat
ion underscores the importance of aggressive syphilis control in correction
al settings, even in the face of declining local early syphilis rates.