As. El-madhun et al., The effect of age and natural priming on the IgG and IgA subclass responses after parenteral influenza vaccination, J INFEC DIS, 180(4), 1999, pp. 1356-1360
This study investigated the effect of natural priming and age on serum IgG
and IgA subclass responses after parenteral trivalent influenza vaccination
. Sera from 18 young children and 8 adults were collected at various times
after vaccination. An ELISA was performed to quantify the concentrations of
antibody subclasses. The children were divided into primed and unprimed gr
oups based on the presence of prevaccination serum antibodies. In both chil
dren and adults, IgG1 and IgA1 were the predominant IgG and IgA subclasses
detected after vaccination. No IgG2 responses were detected in sera of unpr
imed children, and the proportion of the IgG2 response was lower in primed
children than in adults. This suggests that the IgG2 immune response in you
ng children is dependent on previous priming and may mature later than the
other IgG subclasses after parenteral influenza vaccination.