THE TRANSCRIPTIONAL COACTIVATOR P CIP BINDS CBP AND MEDIATES NUCLEAR-RECEPTOR FUNCTION/

The functionally conserved proteins CBP and p300 act in conjunction wi th other factors to activate transcription of DNA. A new factor, p/CIP , has been discovered that is present in the cell as a complex with CE P and is required for transcriptional activity of nuclear receptors an d other CBP/p300-dependent transcription factors. The highly related n uclear-receptor co-activator protein NCoA-1 is also specifically requi red for ligand-dependent activation of genes by nuclear receptors, p/C IP, NCoA-1 and CBP all contain related leucine-rich charged helical in teraction motifs that ape required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signa l-transduction pathways.