P. Petrini et al., Linear poly(ethylene oxide)-based polyurethane hydrogels: polyurethane-ureas and polyurethane-amides, J MAT S-M M, 10(10-11), 1999, pp. 635-639
Citations number
9
Categorie Soggetti
Multidisciplinary
Journal title
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Over the last 30 years, water-swellable and water-insoluble hydrogels have
been extensively investigated and developed, leading to a large family of m
aterials which have found uses in a wide range of biomedical applications.
While hydrogels usually present a crosslinked structure, linear polyurethan
e-ureas (PUUs) based on poly(ethylene oxide) have been shown to be able to
absorb and swell with aqueous media without dissolving. This behavior is du
e to the phase separated domain morphology, where hydrogen bonded urethane/
urea hard segment domains are dispersed in a PEO soft segment domain.
This work investigates the possibility of obtaining linear poly(ethylene ox
ide)-based polyurethane-amide (PUA) hydrogels using two amide diols as chai
n extenders, a mono amide diol (AD) and a diamide diol (DD), and a dicarbox
ylic acid (maleic acid, MA). Poly(ethylene oxide) based PUAs were obtained
using a "one-shot" bulk polymerization technique. The chemicophysical chara
cterization and water-solubility tests showed that these materials, while h
aving molecular weights similar to the PUUs, do not possess sufficient phas
e separation, hydrogen bonding and hydrophobicity of the hard segment domai
ns to exhibit hydrogel behavior. Crosslinked PUAs using maleic acid as chai
n extender show interesting hydrogel properties. (C) 1999 Kluwer Academic P
ublishers.