Response of asymptomatic cytomegalovirus viraemia to oral ganciclovir 3 g/day or 6 g/day in HIV-infected patients

Reactivation of cytomegalovirus (CMV) following immunosuppression may resul t in the development of CMV disease and is associated with an increased ris k of death. CMV viraemia detected by the polymerase chain reaction (PCR) pr ecedes CMV disease in HIV-infected patients and identifies individuals at h igh risk of disease. Pre-emptive ganciclovir (GCV) therapy in patients who have evidence of CMV viraemia is effective in preventing disease. An open s tudy was conducted to assess the response of CMV viraemia to oral GCV at a dose of 3 or 6 g/day for 28 days. HIV RNA was measured to determine if CMV inhibition affected HIV viral load. Fourteen patients were studied, three o f whom entered both phases of the study. None of the patients had evidence of CMV disease at the time of entry into the trial; two patients developed CMV retinitis after completion of the trial. Oral GCV at both 3 and 6 g/day caused a decrease in CMV viral load in individual patients. However, a reb ound in CMV viral load occurred in patients receiving the 3-g/day dose. Non e of the patients receiving oral GCV 3 g/day became PCR negative after 21 d ays compared with six of eight patients receiving 6 g/day. Five of eight pa tients (63%) receiving GCV 6 g/day were concurrently taking protease inhibi tors compared with two of nine (22%) receiving 3 g/day. Ten patients remain ed PCR negative throughout follow up. No change was found in HIV viral load during receipt of GCV at either dose. Thus, oral GCV is effective in reduc ing CMV viral load, but a dose of 3 g/day is insufficiently potent for pre- emptive therapy. (C) 1999 Wiley-Liss, Inc.