Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy

We report for the first time a measured volumetric reduction of a choroid p lexus carcinoma utilizing preoperative chemotherapy. Histologically proven choroid plexus carcinoma was diagnosed in a fifteen month old female. She w as treated with three courses of chemotherapy including etoposide (VP16), c yclophosphamide, vincristine, and cisplatin. Computer-assisted three dimens ional reconstruction of the tumor volume was performed prior to and after t hree courses of chemotherapy. An overall reduction of 29.5% of tumor volume was accomplished preoperatively. Staged surgical procedures resulted in a complete resection of her lesion and she has remained disease-free for 31 m onths. A volumetric measurement as a response to preoperative chemotherapy may prove valuable in determining future optimal treatment regimens for cho roid plexus carcinoma of childhood.