A premature infant exposed to carbamazepine in utero had a markedly undersi
zed brain on cranial ultrasonogram. Postmortem examination of the brain rev
ealed no evidence of hypoxic-ischemic injury, hemorrhage, infarction, conge
nital infection, or calcification. The normal cortical gyral pattern, norma
l residual germinal matrix, and normal cortical lamination suggested the di
agnosis of a radial microbrain form of micrencephaly.