Solubilization of fluasterone

Solubilization of nonpolar drugs constitutes one of the most important task s in parenteral formulations design. This study investigates and assesses t he solubility enhancement of Fluasterone by various techniques including co solvency, micellization, and complexation. Of the solubilizing agents used, the modified beta-cyclodextrins were found to be the most effective. The s olubility of Fluasterone is 1.55 x 10(-4) mM, 3.13 mM, and 4.04 mM in water , 20% sulfobutyl ether-beta-cyclodextrin (SBE beta CD), and 20% hydroxyprop yl-beta-cyciodextrin (HP beta CD), respectively.