What is the capability of transpupillary thermotherapy (TTT) in the treatment of flat choroidal melanomas at the posterior pole? A survey of the current literature
M. Gruterich et al., What is the capability of transpupillary thermotherapy (TTT) in the treatment of flat choroidal melanomas at the posterior pole? A survey of the current literature, KLIN MONATS, 215(3), 1999, pp. 147-151
Backround Transpupillary thermotherapy is a relatively new method far the t
reatment of choroidal melanomas. We present a systematic survey of the curr
ent literature.
Method A temperature rise in the tumor ranging from 45-60 degrees C is achi
eved by an infrared laser beam delivered through the dilated pupil. With a
modified delivery system beam widths between 1 and 3 mm and exposure times
of one minute are generated. Thus, tumors of up to 4 mm thickness are treat
able. TTT can be used as a single treatment procedure or in combination wit
h brachytherapy. Results: Several studies presented in the literature show
a satisfactory local tumor control. However, there is a significant risk of
vision threatening side effects like retinal vascular occlusion or retinal
traction in selected cases.
Conclusion The TTT is a minimal invasive procedure for the treatment of fla
t choroidal melanomas of the posterior pole which is capable of achieving a
good local tumor control. Studies with more patients and longer follow-up
will demonstrate if TTT is also beneficial in the longterm management of ch
oroidal melanomas.