Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin

Authors
Geusau, A Tschachler, E Meixner, M Sandermann, S Papke, O Wolf, C Valic, E Stingl, G McLachlan, M
Citation
A. Geusau et al., Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin, LANCET, 354(9186), 1999, pp. 1266-1267
Citations number
5
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
354
Issue
9186
Year of publication
1999
Pages
1266 - 1267
Database
ISI
SICI code
0140-6736(19991009)354:9186<1266:OIFEO2>2.0.ZU;2-N
Abstract
Two patients with chloracne had concentrations of 2,3,7,8- tetrachlorodiben zo-p-dioxin (TCDD) of 144 000 and 26 000 pg/g blood lipids. Olestra, a non- digestible, lipophilic dietary fat substitute accelerated the patients' int estinal excretion of TCDD by eight to ten fold. This is sufficient to reduc e the normally observed elimination half life of TCDD from about 7 years to 1-2 years.