Accurate and rapid quantitative dynamic contrast-enhanced breast MR imaging using spoiled gradient-recalled echoes and bookend T-1 measurements

A method is presented that converts dynamic T-1-weighted spoiled gradient-r ecalled echo (SGRE) image intensities into estimates of T-1 without the err ors associated with imperfections In the slice profile and transmitter coil magnetic field (B-1). The method Involves T-1 measurements performed befor e and after a series of dynamic SGRE images. These measurements serve to ca librate and correct the SGRE signal strength equation used to estimate T-1. Simulations and phantom experiments were performed to test the method for slice-selective (two-dimensional) and slab-selective (three-dimensional) im aging, as well as for imaging performed with optimized and un-optimized B-1 . For nearly air test conditions, T-1 was estimated accurately (within 10%) over a range of T-1 values expected in vivo (similar to 1200 --> 300 msec) . This method should be useful for quantifying dynamic SGRE imaging for man y different applications Including breast NIR imaging. Magn Reson Med 42:74 6-753, 1999. (C) 1999 Wiley-Liss, Inc.