L. Novotny et al., Separation of structurally related flavonoids by GC/MS technique and determination of their polarographic parameters and potential carcinogenicity, NEOPLASMA, 46(4), 1999, pp. 231-236
The present study deals with the investigation of the naturally occurring d
erivatives of the benzo[b]pyran-4-one - flavonoids - chrysin, tectochrysin
and galangin, and with the effect of minor changes in their chemical struct
ure on their separation using GC/MS. In the relation to their close chemica
l structure, their basic polarographic parameters were also investigated. T
heir potential carcinogenicity index tg alpha was determined by DC polarogr
aphy experiments in the presence of alpha-lipoic acid. The tg alpha values
for chrysin, tectochrysin and galangin were all under 0.180. This indicates
a very minor carcinogenic potential that does not prevent the use of the i
nvestigated flavonoids in human.