Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis

Authors
Fernandez-Arquero, M Arroyo, R Rubio, A Martin, C Vigil, P Conejero, L Figueredo, MA de la Concha, EG
Citation
M. Fernandez-arquero et al., Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis, NEUROLOGY, 53(6), 1999, pp. 1361-1363
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
53
Issue
6
Year of publication
1999
Pages
1361 - 1363
Database
ISI
SICI code
0028-3878(19991012)53:6<1361:PAOATG>2.0.ZU;2-P
Abstract
The associations of three promoter polymorphisms in the tumor necrosis fact or (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and the TNFA- 376 polymorphism. This association was independent of the human leukocyte a ntigen (HLA) class II association and the combined inheritance of HLA-DRB1* 1501 and the TNFA-376A allele more than additively increased susceptibility to MS.