LISTERIA-MONOCYTOGENES INFECTION IN MICE TREATED WITH PENTOXIFYLLINE

Authors
BRZYCHCY M KLINK M TCHORZEWSKI H RUDNICKA W
Citation
M. Brzychcy et al., LISTERIA-MONOCYTOGENES INFECTION IN MICE TREATED WITH PENTOXIFYLLINE, Zentralblatt fur Bakteriologie, 285(4), 1997, pp. 491-500
Citations number
33
Categorie Soggetti
Microbiology,Virology
Journal title
Zentralblatt fur Bakteriologie → ACNP
ISSN journal
09348840
Volume
285
Issue
4
Year of publication
1997
Pages
491 - 500
Database
ISI
SICI code
0934-8840(1997)285:4<491:LIIMTW>2.0.ZU;2-J
Abstract
The course of L. monocytogenes infection was followed in mice treated with pentoxifylline (POF), a known inhibitor of endogenous tumor necro sis factor (TNF) formation. Administration of POF caused a delay in L. monocytogenes elimination which was probably related to a reduction t he listericidal activity of macrophages and to an attenuation of delay ed type hypersensitivity (DTH) to Listeria antigens. In spite of this, some POP-treated mice were protected from lethal effects of virulent L. monocytogenes bacteria.