The original application of wavelets in statistics was to the estimation of
a curve given observations of the curve plus white noise at 2(J) regularly
spaced points. The rationale for the use of wavelet methods in this contex
t is reviewed briefly. Various extensions of the standard statistical metho
dology are discussed. These include curve estimation in the presence of cor
related and non-stationary noise, the estimation of (0-1) functions, the ha
ndling of irregularly spaced data and data with heavy-tailed noise, and def
ormable templates in image and shape analysis. Important tools are a Bayesi
an approach, where a suitable prior is placed on the wavelet expansion, enc
apsulating the notion that most of the wavelet coefficients are zero; the u
se of the non-decimated, or translation-invariant, wavelet transform; and a
fast algorithm for finding all the within-level covariances within the tab
le of wavelet coefficients of a sequence with arbitrary band-limited covari
ance structure. Practical applications drawn from neurophysiology, meteorol
ogy and palaeopathology are presented. Finally, some directions for possibl
e future research are outlined.