Fa. Attaby et al., Synthesis and antimicrobial evaluation of several new pyridine, thienopyridine and pyridothienopyrazole derivatives, PHOSPHOR SU, 149, 1999, pp. 49-64
Citations number
11
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
The reaction of thiocyanoacetamide (1) with alpha,beta-unsaturated ketones
2a,b resulted in the formation of the corresponding newly synthesized 1(H)p
yridinethione derivatives 3a,b. Compounds 3a,b were used as synthons for th
e preparation of 2-S-alkyl-, 2-S-aryl-, 2-S-acetamidopyridine, thieno[2,3-b
]pyridine and pyrazolo[3,4-b]pyridine derivatives via a wide range of react
ions with different reagents. The antimicrobial activity of some of the new
ly synthesized compounds was tested. Compounds 3a, 11a, 15a, and 19a,b were
found to be the most active ones.