Sr. Bornstein et al., MORPHOLOGICAL AND FUNCTIONAL-STUDIES OF THE PARACRINE INTERACTION BETWEEN CORTEX AND MEDULLA IN THE ADRENAL-GLAND, Microscopy research and technique, 36(6), 1997, pp. 520-533
Within the last years it has become evident that besides the hypothala
mo-pituitary-adrenal axis, extrapituitary mechanisms exist that regula
te the activity of the adrenal cortex. In this context, intra-adrenal
regulatory mechanisms play an important role. Several secretory produc
ts from adrenomedullary cells are able to influence adrenocortical ste
roidogenesis. Since the main blood flow within the adrenal is directed
centripetally from the cortex to the medulla, chromaffin cells should
act on cortical cells in a paracrine manner. The morphological prereq
uisite for this regulatory pathway is seen in the close apposition of
the two tissues. within the mammalian adrenal, the two endocrine tissu
es are interwoven to an astonishing degree with cortical cells located
within the medulla and vice versa. It is concluded from morphological
and functional studies that paracrine interactions between cortex and
medulla play an important role in the regulation of adrenocortical st
eroidogenesis. (C) 1997 Wiley-Liss, Inc.