Twenty-two cases were reviewed in which the diagnosis of radial scar (compl
ex sclerosing lesion) of the breast was suspected preoperatively. At mammog
raphy, the lesions had a "black star" appearance with long, thin spicules r
adiating from a radiolucent central area. Excisional rather than core needl
e biopsy was recommended in all cases. In 13 of 22 cases, including one cas
e of atypical ductal hyperplasia, the lesions proved benign at pathologic a
nalysis. The remaining nine cases were malignant and included one case with
a low-nuclear-grade cribriform and micropapillary ductal carcinoma in situ
adjacent to the lesion. Results of this study confirm the previously repor
ted association of atypical ductal hyperplasia and carcinoma with radial sc
ar. Furthermore, they demonstrate that a mammographic finding suggestive of
radial scar may represent a malignancy that mimics the typical imaging fin
dings in these entities. In cases of mammographically suspected radial scar
, all members of the management team as well as the patient should be made
aware preoperatively of the potential for benign as well as malignant patho
logic findings.