Langerhans cell histiocytosis in the central nervous system: meningeal involvement

The clinical manifestations of Langerhans cell histiocytosis in the central nervous system include not only the classical involvement of the hypothala mus-hypophyseal axis, but also of other anatomic locations, with the corres ponding variability of symptoms. We report here two patients with meningeal lesions. In both patients, the o nset of the disease was systemic, and neurological symptoms developed some years later. Imaging studies, particularly magnetic resonance, are very sen sitive tools for the diagnosis and follow-up of these lesions. The natural history of this disease is still poorly understood. In this pap er we related the clinical manifestations to the morphological changes obse rved in imaging studies.