The role of prostanoids in the development of diabetic embryopathy

In infants Of diabetic mothers, congenital anomalies occur about two-three times as often as in normal population. Many etiologic factors have been pr oposed regarding the mechanism of diabetes related birth defects. The metab olic alterations associated with hyperglycemia include myo-inositol and ara chidonic acid deficiency, and as a result disturbed metabolism of prostagla ndins. Recent studies provide evidence that a deficiency in prostaglandins adversely affects membranogenesis and membrane function. These changes in m embrane function permit the influx of high levels of glucose into the cells , inducing the generation of free oxygen radicals that cause morphologic da mage of the embryo, involving aberrant mitochondrial function and enhanced peroxidation of embryonic lipids. The functional deficiency of prostaglandi ns at a critical time of fetal development can cause embryonic malformation s. This paper reviews the role of prostanoids in the development of diabeti c embryopathy.