Osteosarcoma in a patient with McCune-Albright syndrome and Mazabrand's syndrome

Sarcomas infrequently develop in osseous sites of fibrous dysplasia. We rep ort a patient with Mazabraud's syndrome (polyostotic fibrous dysplasia and soft tissue myxomas) complicated by the development of osteogenic sarcoma i n a bone affected by fibrous dysplasia. This is the third case of osteosarc oma within the small population of reported patients with Mazabraud's syndr ome. There may be an increased incidence of malignant transformation in the se individuals' dysplastic bones above that associated with patients suffer ing from fibrous dysplasia alone.