Background: There is growing concern about increase in illicit drug use and
associated fatalities in young people. Method: This longitudinal analysis
of successive cohorts of addicts in England and Wales aged 15-19 years foll
owed up over a 20-year period covering 1974 to 1993 (1) investigated trends
in all-causes mortality; (2) examined teenage-specific mortality, i.e. dea
ths during ages 15-19 years; (3) determined excess teenage-specific mortali
ty; and (3) identified the main underlying causes of teenage-specific death
in this population. The main outcome measures were overall mortality rates
, teenage-specific mortality and standardised mortality ratios calculated f
or four 5-year (period) successive cohorts. Results: Overall mortality rate
in the study population (N = 9491) was 4.7/1000 person-years. The median a
ge at death was 23 years (semi interquartile range = 3), with the majority
(91.3%) of deaths occurring between ages 15 and 29 years. Excess teenage-sp
ecific mortality in the population was 10.7 in males and 21.2 in females (g
eneral population = 1), and increase in excess mortality in both sexes was
evident in the last 5-year period of study. The majority of deaths (63.3%)
resulted from accidental poisoning. Methadone and heroine/morphine accounte
d for about two-thirds of accidental poisoning deaths, while suicide accoun
ted for 11.4% of teenage-specific deaths. Conclusions: It is strongly recom
mended that treatment services should be more responsive to the need for ca
reful prescribing, dispensing and administration of substitute medication t
o teenage addicts in their care. The development of needs-led, case-sensiti
ve treatment services for young addicts is indicated.