A stereocontrolled route to (-)-epibatidine using a chiral cis-cyclohexadiene-1,4-diol equivalent

Authors
Nakashima, H Hiroya, K Taniguchi, T Ogasawara, K
Citation
H. Nakashima et al., A stereocontrolled route to (-)-epibatidine using a chiral cis-cyclohexadiene-1,4-diol equivalent, SYNLETT, (9), 1999, pp. 1405-1406
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
9
Year of publication
1999
Pages
1405 - 1406
Database
ISI
SICI code
0936-5214(199909):9<1405:ASRT(U>2.0.ZU;2-T
Abstract
A concise diastereo- and enantio-controlled synthesis of (-)-epibatidine, t he potent analgesic alkaloid from an Ecuadoran poison frog, Epipedobates tr icolor, has been developed starting with a synthetic equivalent of chiral c is-cyclohexadiene- 1,4-diol.