AN ALTERNATE ENANTIOSPECIFIC SYNTHESIS OF METHYL DRO-4-METHYL-3-OXO-1H-1,4-BENZODIAZEPINE-2-ACETATE

Authors
KU TW ALI FE BONDINELL WE ERHARD KF HUFFMAN WF VENSLAVSKY JW YUAN CCK
Citation
Tw. Ku et al., AN ALTERNATE ENANTIOSPECIFIC SYNTHESIS OF METHYL DRO-4-METHYL-3-OXO-1H-1,4-BENZODIAZEPINE-2-ACETATE, Tetrahedron letters, 38(18), 1997, pp. 3131-3134
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
18
Year of publication
1997
Pages
3131 - 3134
Database
ISI
SICI code
0040-4039(1997)38:18<3131:AAESOM>2.0.ZU;2-E
Abstract
An alternate enantiospecific synthesis of methyl dro-4-methyl-3-oxo-1H -1,4-benzodiazepine-2-acetate (5) is reported. The key step, which inv olves an intermolecular displacement of the activated aryl fluoride (9 ) by L-aspartic acid beta-methyl ester, proceeds without racemization. (C) 1997 Elsevier Science Ltd.