CRYSTAL ENGINEERING FOR ABSOLUTE ASYMMETRIC-SYNTHESIS THROUGH THE USEOF META-SUBSTITUTED ARYL GROUPS

Authors
WU LC CHEER CJ OLOVSSON G SCHEFFER JR TROTTER J WANG SL LIAO FL
Citation
Lc. Wu et al., CRYSTAL ENGINEERING FOR ABSOLUTE ASYMMETRIC-SYNTHESIS THROUGH THE USEOF META-SUBSTITUTED ARYL GROUPS, Tetrahedron letters, 38(18), 1997, pp. 3135-3138
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
18
Year of publication
1997
Pages
3135 - 3138
Database
ISI
SICI code
0040-4039(1997)38:18<3135:CEFAAT>2.0.ZU;2-5
Abstract
A significant tendency towards crystallization in chiral space groups has been found for 4-benzyloxy-2-pyridones whose phenyl groups are met a-substituted (m-Cl, m-Br, m-Me and m-OMe). Irradiation of single crys tals of three of these materials leads to optically active beta-lactam derivatives in high chemical and optical yields via an allowed disrot atory electrocyclization. (C) 1997 Elsevier Science Ltd.