AN EFFICIENT AND VERSATILE SYNTHESIS OF PIPERAZINE-2-CARBOXAMIDES

Authors
ROSSEN K SAGER J DIMICHELE LM
Citation
K. Rossen et al., AN EFFICIENT AND VERSATILE SYNTHESIS OF PIPERAZINE-2-CARBOXAMIDES, Tetrahedron letters, 38(18), 1997, pp. 3183-3186
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
18
Year of publication
1997
Pages
3183 - 3186
Database
ISI
SICI code
0040-4039(1997)38:18<3183:AEAVSO>2.0.ZU;2-7
Abstract
An efficient and versatile synthesis of piperazine-2-carboxamides 5 is described. The preparation consists of a one-pot, 4-component Ugi con densation between an N-alkylethylenediamine 1, chloroacetaldehyde (2), an isonitrile 3 and a carboxylic acid 4. (C) 1997 Elsevier Science Lt d.