beta-amino acid facilitates macrocyclic ring closure in a combinatorial library

Authors
Jefferson, EA Swayze, EE
Citation
Ea. Jefferson et Ee. Swayze, beta-amino acid facilitates macrocyclic ring closure in a combinatorial library, TETRAHEDR L, 40(44), 1999, pp. 7757-7760
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
44
Year of publication
1999
Pages
7757 - 7760
Database
ISI
SICI code
0040-4039(19991029)40:44<7757:BAFMRC>2.0.ZU;2-5
Abstract
A solid phase synthesis of 14-membered macrocycles, resulting from resin-bo und protected amino alcohols is described. A nucleophilic aromatic substitu tion strategy was used to effect the macrocyclization. (C) 1999 Elsevier Sc ience Ltd. All rights reserved.