Oligonucleotide N3 '-> P5 ' thiophosphoramidates: synthesis and properties

Authors
Pongracz, K Gryaznov, S
Citation
K. Pongracz et S. Gryaznov, Oligonucleotide N3 '-> P5 ' thiophosphoramidates: synthesis and properties, TETRAHEDR L, 40(43), 1999, pp. 7661-7664
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
43
Year of publication
1999
Pages
7661 - 7664
Database
ISI
SICI code
0040-4039(19991022)40:43<7661:ON'P'T>2.0.ZU;2-0
Abstract
Uniformly modified oligonucleotides with a novel sugar-phosphate backbone c ontaining internucleoside 3'-NHP(O)(S-)O-5' linkages were synthesized. Thes e oligonucleotides were found to retain the high RNA binding affinity of th e parent oligonucleotide N3'-->P5' phosphoramidates and to exhibit a much h igher acid stability. (C) 1999 Elsevier Science Ltd. All rights reserved.