Solution and solid-phase synthesis of hydroxamic acids via palladium catalysed cascade reactions

The elaboration of a series of aryl iodides into heterocyclic hydroxamates proceeds in good to excellent yield in a palladium catalysed termolecular c ascade reaction involving carbon monoxide and protected hydroxylamines. Dep rotection affords a range of novel heterocyclic hydroxamic acids. In a rela ted process, N-benzyloxyimides were synthesised in a pentamolecular cascade . The hydroxamic acids were also synthesised using resin-bound hydroxylamin e derivatives in a solid-phase cascade process. (C) 1999 Elsevier Science L td. All rights reserved.