Effect of base concentration on the rate of the vicarious nucleophilic substitution of hydrogen and on the kinetic isotope effect.

Authors
Makosza, M Lemek, T Kwast, A
Citation
M. Makosza et al., Effect of base concentration on the rate of the vicarious nucleophilic substitution of hydrogen and on the kinetic isotope effect., TETRAHEDR L, 40(42), 1999, pp. 7541-7544
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
42
Year of publication
1999
Pages
7541 - 7544
Database
ISI
SICI code
0040-4039(19991015)40:42<7541:EOBCOT>2.0.ZU;2-D
Abstract
Varying concentration of the chloromethyl tolyl sulfone carbanion influence s the rate of its VNS reaction with 2-fluoro-4-bromonitrobenzene and change s the mechanistic scheme from thermodynamic to kinetic control. Both primar y and secondary kinetic isotope effects are observed and are clearly connec ted with particular kinetic relations. (C) 1999 Elsevier Science Ltd. AII r ights reserved.