A new asymmetric synthesis of (+)-grandisol via a kinetic resolution.

Authors
Hamon, DPG Tuck, KL
Citation
Dpg. Hamon et Kl. Tuck, A new asymmetric synthesis of (+)-grandisol via a kinetic resolution., TETRAHEDR L, 40(42), 1999, pp. 7569-7572
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
42
Year of publication
1999
Pages
7569 - 7572
Database
ISI
SICI code
0040-4039(19991015)40:42<7569:ANASO(>2.0.ZU;2-C
Abstract
A novel approach to the asymmetric synthesis of (+)-grandisol involves the use of catalytic kinetic resolution of a primary allylic alcohol. The allyl ic alcohol is prepared in 4 steps from simple achiral materials and the res olved alcohol (95%e.e.) is reduced in 2 steps to the corresponding methyl a lkene. This alkene is converted to (+)-grandisol (95%e.e.). (C) 1999 Elsevi er Science Ltd. All rights reserved.