Versatile synthesis of (+)-deoxypyridinoline, a biochemical marker for diagnosis of osteoporosis

Authors
Adamczyk, M Akireddy, SR Reddy, RE
Citation
M. Adamczyk et al., Versatile synthesis of (+)-deoxypyridinoline, a biochemical marker for diagnosis of osteoporosis, TETRAHEDR-A, 10(16), 1999, pp. 3107-3110
Citations number
36
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
16
Year of publication
1999
Pages
3107 - 3110
Database
ISI
SICI code
0957-4166(19990813)10:16<3107:VSO(AB>2.0.ZU;2-R
Abstract
A versatile chiral synthesis of the bone collagen cross-link, (+)-deoxypyri dinoline (Dpd, 1) was described starting from a 3-hydroxypyridine derivativ e (2) via sequential introduction of three amino acid chains followed by hy drolysis. The key synthon 2, was prepared from vitamin B-6 (6). (C) 1999 Pu blished by Elsevier Science Ltd. All rights reserved.