A NEW SYNTHETIC ANALOG OF THE BRACKEN ULTIMATE CARCINOGEN - ELEVATIONOF STABILITY AND ALTERATION OF DNA ALKYLATION SITE SELECTIVITY

Authors
KIGOSHI H KITAMURA Y FUJITA T OHASHI H ATSUMI T TAKAGI J MUTOU T YAMADA K KUSAKABE T SASAKI D SUGIURA Y
Citation
H. Kigoshi et al., A NEW SYNTHETIC ANALOG OF THE BRACKEN ULTIMATE CARCINOGEN - ELEVATIONOF STABILITY AND ALTERATION OF DNA ALKYLATION SITE SELECTIVITY, Tetrahedron letters, 38(18), 1997, pp. 3235-3238
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
18
Year of publication
1997
Pages
3235 - 3238
Database
ISI
SICI code
0040-4039(1997)38:18<3235:ANSAOT>2.0.ZU;2-Q
Abstract
The benzodienone 4 as a stable analogue of the bracken ultimate carcin ogen (2) has been designed and synthesized. In the reaction with DNA t he compound 4 was found to give only the N-7 alkylated product of guan ine and no N-3 alkylated product of adenine and reveal guanine-selecti ve cleavage in contrast to the natural dienone 2. (C) 1997 Elsevier Sc ience Ltd.