N-FMOC-AMINOOXY-2-CHLOROTRITYL POLYSTYRENE RESIN - A FACILE SOLID-PHASE METHODOLOGY FOR THE SYNTHESIS OF HYDROXAMIC ACIDS

Authors
MELLOR SL MCGUIRE C CHAN WC
Citation
Sl. Mellor et al., N-FMOC-AMINOOXY-2-CHLOROTRITYL POLYSTYRENE RESIN - A FACILE SOLID-PHASE METHODOLOGY FOR THE SYNTHESIS OF HYDROXAMIC ACIDS, Tetrahedron letters, 38(18), 1997, pp. 3311-3314
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
18
Year of publication
1997
Pages
3311 - 3314
Database
ISI
SICI code
0040-4039(1997)38:18<3311:NPR-AF>2.0.ZU;2-W
Abstract
Using the new compound N-Fmoc-hydroxylamine 1 we have generated a faci le route to a high loading, acid labile solid-phase resin bearing a hy droxylamine linker. The novel N-Fmoc-aminooxy-2-chlorotrityl polystyre ne 2 showed generic utility for the construction of hydroxamic acids, including peptidyl hydroxamic acids. (C) 1997 Elsevier Science Ltd.