La. Wallace, HUMAN EXPOSURE AND BODY BURDEN FOR CHLOROFORM AND OTHER TRIHALOMETHANES, Critical reviews in environmental science and technology, 27(2), 1997, pp. 113-194
Existing information on human exposure to chloroform and other trihalo
methanes (THMs) in air, water, and food is summarized. Three major sur
veys have collected data on chloroform levels in finished water at tre
atment plants. EPA's TEAM Studies have measured concentrations of THMs
in residential drinking water and in personal, indoor, outdoor, and e
xpired air from about 800 participants in eight cities. The Food and D
rug Administration has surveyed chloroform levels in food and beverage
s. Recently, the Centers for Disease Control (CDC) have completed meas
uring blood levels of THMs in about 1000 participants in the National
Health and Nutrition Examination Survey (NHANES). Exposure occurs thro
ugh ingestion (drinking tap water and soft drinks and eating certain d
airy foods), inhalation (breathing peak amounts of chloroform emitted
during showers or baths, and lower levels in indoor air from other ind
oor sources), and dermal absorption (during showers, baths, and swimmi
ng). Each of these routes of exposure appear to be potentially substan
tial contributors to total exposure. The major source of exposure to c
hloroform is chlorination of water supplies. This results in exposure
through ingestion of drinking water, but also through inhalation and s
kin absorption as a result of the myriad other uses of chlorinated wat
er in the home: showers, baths, washing clothes and dishes, etc. Becau
se chlorinated water supplies are used by bottling plants of soft drin
k manufacturers, even the chloroform found in beverages may be partial
ly due to the chlorination of water supplies. Other sources of exposur
e, which can be important for specific groups of people, include chlor
ination of swimming pools, industrial production and use, and use of b
leach during clothes washing.